Publications of Interest

Below is a sampling of publications relevant to the plasma gelsolin technology platform.

1. Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function. Yang Z, Chiou TT-Y, Stossel TP, Kobzik L. American Journal of Physiology Lung Cellular and Molecular Physiology. 2015;309(1):L11-6. doi: 10.1152/ajplung.00094.2015. PubMed PMID: 25957291 PMCID: PMCPMC4491512.

2. Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction. Rothenbach PA, Dahl B, Schwartz JJ, O’Keefe GE, Yamamoto M, Lee WM, Horton JW, Yin HL, and Turnage RH. J Applied Physiol 96: 25-31, 2004.

3. Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice. Christofidou-Solomidou M, Scherpereel A, Solomides CC, Christie JD, Stossel TP, Goelz S, and Dinubile MJ. J Inv Med 50: 54-60, 2002.


4. Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Osborn TM, Dahlgren C, Hartwig JH, Stossel TP. American Journal of Physiology Cell Physiology. 2007;292(4):C1323-30. doi: 10.1152/ajpcell.00510.2006. PubMed PMID: 17135294.

5. Coordinated inhibition of actin-induced platelet aggregation by plasma gelsolin and vitamin D-binding protein. Vasconcellos CA, Lind SE. Blood. 1993;82(12):3648-57. PubMed PMID: 8260702.

6. Plasma gelsolin and circulating actin correlate with hemodialysis mortality. Lee P-S, Sampath K, Karumanchi SA, Tamez H, Bhan I, Isakova T, Gutierrez OM, Wolf M, Chang Y, Stossel TP, Thadhani R. Journal of the American Society of Nephrology : JASN. 2009;20(5):1140-8. doi: 10.1681/ASN.2008091008. PubMed PMID: 19389844 PMCID: PMCPMC2678046.

7. Relationship of plasma gelsolin levels to outcomes in critically ill surgical patients. Lee P-S, Stossel TP. Annals of Surgery. 2006;243(3):399-403. doi: 10.1097/01.sla.0000201798.77133.55. PubMed PMID: 16495706.

8. Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. Osborn TM, Verdrengh M, Stossel TP, Tarkowski A, Bokarewa M. Arthritis Research & Therapy. 2008;10(5):R117. doi: 10.1186/ar2520. PubMed PMID: 18822171 PMCID: PMCPMC2592804.

9. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, Reed C, Grijalva CG, Anderson EJ, Courtney DM, Chappell JD, Qi C, Hart EM, Carroll F, Trabue C, Donnelly HK, Williams DJ, Zhu Y, Arnold SR, Ampofo K, Waterer GW, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, McCullers JA, Pavia AT, Edwards KM, Finelli L, Team CES. N Engl J Med. 2015;373(5):415-27. doi: 10.1056/NEJMoa1500245. PubMed PMID: 26172429.


10. Therapeutic potential of plasma gelsolin administration in a rat model of sepsis. Cohen TS, Bucki R, Byfield FJ, Ciccarelli NJ, Rosenberg B, Dinubile MJ, Janmey PA, Margulies SS. Cytokine. 2011;54(3):235-8. doi: 10.1016/j.cyto.2011.02.006. PubMed PMID: 21420877 PMCID: PMCPMC3083472.

11. Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Lee P-S, Waxman AB, Cotich KL, Chung SW, Perrella MA, Stossel TP. Critical Care Medicine. 2007;35(3):849-55. doi: 10.1097/01.CCM.0000253815.26311.24. PubMed PMID: 17205019.

12. A Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Trial Of The Pharmacokinetics And Safety Of Intravenous Infusion Of Recombinant Human Plasma Gelsolin In Acutely Ill Patients With Decreased Plasma Gelsolin Levels. Chan W, Lau L, Kwok K, Law W, Ho J, Chu K, Poon R. American Journal of Respiratory and Critical Care Medicine. 2011;A5601:A5601.

13. Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. Journal of immunology Bucki R, Byfield FJ, Kulakowska A, McCormick ME, Drozdowski W, Namiot Z, Hartung T, Janmey PA. (Baltimore, Md : 1950). 2008;181(7):4936-44. PubMed PMID: 18802097.