The recent review article, “Evolving Understanding of the Causes of Pneumonia in Adults, With Special Attention to the Role of Pneumococcus” in the November 15, 2017 Clinical Infectious Diseases, addresses the trends and current status of the etiology of Community Acquired Pneumonia (CAP). These data support the need for a pathogen-agnostic/host-based approach to the disease, such as BioAegis’ plasma gelsolin program. Three of the most recent studies, including the CDC’s EPIC Study published in July 2015 New England Journal of Medicine, underscore the failure to identify a causative pathogen in greater than 50% of the cases. Streptococcus pneumoniae remains the most commonly identified pathogen, although it is demonstrated in <20% of cases. Numerous other gram-positive and gram-negative bacteria are less frequently recovered. Viruses are found in 25% of the patients, either alone or as a coinfection. These findings have implications for antibiotic stewardship and strongly reinforce the need for a host-based approach to this disease as a whole.
- October, 2019: BioAegis Therapeutics Named New Jersey’s Most Valuable Venture-Backed Company Led by a Woman
- August, 2019: BioAegis Therapeutics Announces Publication in the Journal of Infectious Diseases: “Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Sensitive and Resistant Pneumococcal Pneumonia”
- August, 2019: BioAegis Therapeutics Reports Favorable Safety and Pharmacokinetic Results in its Phase 1b/2a Dose-Escalation Study of Recombinant Human Plasma Gelsolin with Highest Doses Ever Administered to Patients
- April, 2019: BioAegis Therapeutics Receives US Patent Protection for the Therapeutic Uses of Plasma Gelsolin in Renal Failure
- March 2019: BioAegis Therapeutics Completes Enrollment in its Phase 1b/2a Dose-Ranging Safety Study of Recombinant Plasma Gelsolin for Community-Acquired Pneumonia